COURSE:

NR546 – Advanced Pharmacology: Psychopharmacology

Preparing the Assignment

Follow these guidelines when completing each component of the assignment. Contact your course faculty if you have questions.

General Instructions

Download the Week 4 Medication Table. and complete the required information using the template.

Include the following sections (detailed criteria listed below and in the grading rubric)

For each medication listed, complete the following:
1. Provide indication, target symptoms, and affected neurotransmitters.
2. Include half-life and CYP 450 enzyme information.
3. List notable side effects.
4. Link notable side effects to the associated pathway or neurotransmitter.

Submit your completed medication table to the Week 4 dropbox.

Solution

Drug Name/

Medication class

Indication

list diagnosis and targeted symptoms

Associated Neurotransmitters

Half-life (T1/2)

Metabolism (CYP 450 enyzme)

Notable side effects

Gabapentin

Indication:

·Partial seizures with or without secondary generalization (adjunctive)

·Postherpetic neuralgia

·Restless leg syndrome

·Neuropathic pain/chronic pain

·Anxiety (adjunctive)

·Bipolar disorder (adjunctive)

Target symptoms:

·Seizures

·Pain

·Anxiety

Associated neurotransmitters:

·Leucine analog transported both into the blood from the gut and also across the blood-brain barrier into the brain from the blood by the system L transport system

·Binds to the alpha 2 deltasubunit of voltage-senitive calcium channels

·This closes N and P/Qpresynaptic calcium channels, diminishing excessive neuronal activity and neurotransmitter release

·Although structurally related to gamma-amniobutryic acid (GABA), no known direction actions on GABA or its receptors

Half-life:

5-7 hours

Metabolism: Notmetabolized;excretedintact renally

Notable side effects:

·Sedation (dose-dependent), dizziness

·Ataxia (dose-dependent), fatigue, nystagmus, tremor

·Peripheral edema

·Blurred vision

·Vomiting, dyspepsia, diarrhea, dry mouth, constipation, weight gain ·Additional effects in children under age 12: hostility, emotional lability, hyperkinesia, thought disorder, weight gain

·CNS side effects may be due to excessive blockade of voltage-sensitive calcium channels

……………………………………………………………$5

[Solved] NR546 Week 4: Anxiolytic Medication Table

COURSE: