[Solved] NR546 Week 6: Addiction Medication Table

COURSE:

NR546 – Advanced Pharmacology: Psychopharmacology

Preparing the Assignment

Follow these guidelines when completing each component of the assignment. Contact your course faculty if you have questions.

General Instructions

Download the Week 6 Medication Table. and complete the required information using the template.

Include the following sections (detailed criteria listed below and in the grading rubric)

  1. For each medication listed, complete the following:
    1. Provide indication, target symptoms, and affected neurotransmitters.
    2. Include half-life and CYP 450 enzyme information.
    3. List notable side effects and link notable side effects to the associated pathway or neurotransmitter.
    4. List Initial Dosing Considerations and specific lifespan considerations (age, pregnancy, breastfeeding).

 

Solution

Drug Name

 

 Indication

Neurotransmitter(s) Affected

Target Symptoms

 Half-life (T1/2), Metabolism (CYP 450 enzyme) Notable Side Effects (link to NT or affected brain circuit) Initial Dosing Considerations

Specific lifespan considerations (age, pregnancy, breastfeeding)
Buprenorphine              (Subutex) Indication:

·       Maintenance

treatment of opioid

dependence

·       Maintenance

treatment of opioid

dependence in

patients who have

achieved and

sustainced prolonged

clinical stability on

low-to-moderate

doses of a

transmucosal

buprenorphine containing

product

·       Moderate to severe

opioid use disorder

in patients who have

initiated treatment

with a transmucosal

buprenorphine containing

product,

followed by dose

adjustment for a

minimum of 7 days

Neurotransmitters:

·       Mu opioid receptor

partial agonist

·       Antagonist at the

kappa opioid

receptor

Target symptoms:

Opioid dependence

 Half-life:

24-42

hours

CYP450:

CYP3A4

 ·       Headache,

constipation,

nausea

·       Oral hypoesthesia,

glossodynia

·       Orthostatic

hypotension

·       Implant specific:

insertion site pain,

pruritis, erythema

·       Respiratory

depression

·       Hepatotoxicity

 Initial dosing:

Day 1: 8 mg

Day 2: 12-16 mg

Days 3-7: Increase in

increments of 4 mg,

maximum 32 mg

Considerations:

·       Use with caution

in elderly and

those with cardiac

impairment

·       May be

preferable to

methadone in

pregnant women

·       Neonatal

withdrawal may

occur

·       Drug is found in

breast milk,

recommended to

DC drug or bottle

feed

·       Safety and

efficacy has not

been established

for children and

adolescents

……………………………………………..$5