[Solved] NR546 Week 8: Neurotransmitter Assignment

COURSE:

NR546 – Advanced Pharmacology: Psychopharmacology

Preparing the Assignment

Follow these guidelines when completing each component of the assignment. Contact your course faculty if you have questions.

General Instructions

Download the neurotransmitter table. and complete the required information using the template.

Include the following sections (detailed criteria listed below and in the grading rubric)

  1. For each neurotransmitter and receptor type, complete the following columns:
    1. Location/function/effects/symptoms of excess or deficit
    2. Distribution
    3. Drug classes that target this neurotransmitter or receptor
    4. All neurotransmitters and receptor types: Specific medications that target this neurotransmitter or receptor.

 

Solution

Neurotransmitter Table

* To be completed throughout course and submitted in Week 8*

 

Neuro transmitter Receptor Subtype Location/Function/Effects

/symptoms of excess or deficit if applicable

 Distribution (ie: CNS/PNS,

GI, vascular)

 Drug classes that target this neurotransmitter or

receptor

 Specific medications that target this neurotransmitter or receptor
Glutamate AMPA Ligand-gated ion channels Regulates cell excitability by allowing the flow of calcium and sodium ions into the cell. Located at the CNS in neurons and glia. Excess has resulted in schizophrenia, epilepsy,

and mania.

 CNS NMDA

glutamate antagonist Barbiturates Antiepileptics

 Memantine Dextromethorphan Dextromethadone Parampanel Ketamine
NMDA Ligand-gated ion channels, reinforces synapses and involved in compelling memory formation. Excess is correlated with memory and learning impairments, psychosis, and excitotoxic brain injury. CNS NMDA receptor antagonist Antipsychotics Loop Diuretics Opiates Antidepressants Methadone Dextropropoxyphene Ketobemidone Furosemide

Haldol Tramadol Memantine Amantadine Ketamine

Dextromethorphan
GABA GABA a Ligand-gated ion channels The purpose as postsynaptic inhibition by CI-influx Inotropic receptor Decreases fear,

anxiety, and convulsions

 CNS Limbic system Striatum Medulla Spinal Cord

CNS/PNS

 Benzodiazepines Hypnotics Neuroactive steroids Zolpidem Zopiclone Zaleplon Lorazepam Clonazepam

Alprazolam

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