COURSE:
NR546 – Advanced Pharmacology: Psychopharmacology
Preparing the Assignment
Follow these guidelines when completing each component of the assignment. Contact your course faculty if you have questions.
General Instructions
Download the neurotransmitter table. and complete the required information using the template.
Include the following sections (detailed criteria listed below and in the grading rubric)
- For each neurotransmitter and receptor type, complete the following columns:
- Location/function/effects/symptoms of excess or deficit
- Distribution
- Drug classes that target this neurotransmitter or receptor
- All neurotransmitters and receptor types: Specific medications that target this neurotransmitter or receptor.
Solution
Neurotransmitter Table
* To be completed throughout course and submitted in Week 8*
| Neuro transmitter | Receptor Subtype | Location/Function/Effects
/symptoms of excess or deficit if applicable |
Distribution (ie: CNS/PNS,
GI, vascular) |
Drug classes that target this neurotransmitter or
receptor |
Specific medications that target this neurotransmitter or receptor |
| Glutamate | AMPA | Ligand-gated ion channels Regulates cell excitability by allowing the flow of calcium and sodium ions into the cell. Located at the CNS in neurons and glia. Excess has resulted in schizophrenia, epilepsy,
and mania. |
CNS | NMDA
glutamate antagonist Barbiturates Antiepileptics |
Memantine Dextromethorphan Dextromethadone Parampanel Ketamine |
| NMDA | Ligand-gated ion channels, reinforces synapses and involved in compelling memory formation. Excess is correlated with memory and learning impairments, psychosis, and excitotoxic brain injury. | CNS | NMDA receptor antagonist Antipsychotics Loop Diuretics Opiates Antidepressants | Methadone Dextropropoxyphene Ketobemidone Furosemide
Haldol Tramadol Memantine Amantadine Ketamine Dextromethorphan |
|
| GABA | GABA a | Ligand-gated ion channels The purpose as postsynaptic inhibition by CI-influx Inotropic receptor Decreases fear,
anxiety, and convulsions |
CNS Limbic system Striatum Medulla Spinal Cord
CNS/PNS |
Benzodiazepines Hypnotics Neuroactive steroids | Zolpidem Zopiclone Zaleplon Lorazepam Clonazepam
Alprazolam |
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